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武汉老版本彩名堂计划软件生物科技有限公司

热搜词：燕窝酸，不饱和脂肪酸，神经酰胺，花青素，黄酮，皂苷

Wuhan Chemstan Biotechnology Co., Ltd.

武汉老版本彩名堂计划软件生物科技有限公司

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玛咖酰胺类
 芥子油苷类
 脂肪酸类化合物
 黄酮类化合物
 酚类化合物
异戊烯类化合物
 含氮类化合物
 苯丙素类
 醌类化合物
 糖类化合物

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FG-4592

浏览量:

产品名称：

FG-4592

NO.

货号

CS2515

中文名称

Roxadustat

英文名称

Roxadustat

CAS号

808118-40-3

产品货号：

CS2515

货期：

价格与订购：

480.00

数量

库存

300

产品信息

如何订购

产品描述icon

Roxadustat is an orally bioavailable, hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI), with potential anti-anemic activity.

靶点活性icon

HIF-PH

体内活性icon

FG-4592 (25 mg/kg) enhances mitophagy and attenuates retinal histopathologic damage in the photoreceptor layer after RD in an RD animal model[1].

细胞实验icon

The left eye of each rat is retro-orbitally injected with 25 mg/kg FG-4592 every 2 days, and an equal volume of 20% DMSO diluted with 0.9% NaCl is administrated with retro-orbital injection and served as the control. The retinae (attached, 1 day, 3 days, 5 days, and 7 days after RD) are homogenized and lysed with buffer containing 50 mM hydroxymethyl(Tris)-aminomethane(HCl), 150 mM NaCl, 1% Triton X-100, 1% sodium deoxycholate, 0.1% SDS, and a protease inhibitor tablet. Samples are run on 8% to 12% 2-hydroxyethyl (Bis)-hydroxymethyl (Tris) gel electrophoresis and transferred onto polyvinylidene difluoride (PVDF) membranes (0.2-mm pores). After blocking with 3% nonfat dried milk, the membranes are incubated overnight with primary antibody HIF-1α, LC3, BNIP3, autophagy-related gene 5 (Atg5), and β-actin. The blotted membranes are then incubated for 60 minutes at room temperature with a horseradish peroxidase (HRP)-labeled secondary antibody. Immunoreactive bands are visualized by enhanced chemiluminescence (ECL) and detected with an Amersham Imager 600. A minimum of three rats are used for each condition. icon

别名icon

FG-4592 , ASP1517

纯度icon

>99%

分子量icon

352.34

分子式icon

C24H27F3N8O3

CAS Noicon

808118-40-3

存储icon

Powder: -20°C for 3 years

In solvent: -80°C for 6 months

溶解度
icon

DMSO: 65 mg/mL (184.5 mM)

Ethanol: <1 mg/mL

Water: <1 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

icon

Note
icon

For research use only .

产品描述	Roxadustat is an orally bioavailable, hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI), with potential anti-anemic activity.
靶点活性	HIF-PH
体内活性	FG-4592 (25 mg/kg) enhances mitophagy and attenuates retinal histopathologic damage in the photoreceptor layer after RD in an RD animal model[1].
细胞实验	The left eye of each rat is retro-orbitally injected with 25 mg/kg FG-4592 every 2 days, and an equal volume of 20% DMSO diluted with 0.9% NaCl is administrated with retro-orbital injection and served as the control. The retinae (attached, 1 day, 3 days, 5 days, and 7 days after RD) are homogenized and lysed with buffer containing 50 mM hydroxymethyl(Tris)-aminomethane(HCl), 150 mM NaCl, 1% Triton X-100, 1% sodium deoxycholate, 0.1% SDS, and a protease inhibitor tablet. Samples are run on 8% to 12% 2-hydroxyethyl (Bis)-hydroxymethyl (Tris) gel electrophoresis and transferred onto polyvinylidene difluoride (PVDF) membranes (0.2-mm pores). After blocking with 3% nonfat dried milk, the membranes are incubated overnight with primary antibody HIF-1α, LC3, BNIP3, autophagy-related gene 5 (Atg5), and β-actin. The blotted membranes are then incubated for 60 minutes at room temperature with a horseradish peroxidase (HRP)-labeled secondary antibody. Immunoreactive bands are visualized by enhanced chemiluminescence (ECL) and detected with an Amersham Imager 600. A minimum of three rats are used for each condition.

别名	FG-4592 , ASP1517
纯度	100.00%
分子量	352.34
分子式	C19H16N2O5
CAS No.	808118-40-3

存储